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Unravelling the Main Causes of Knee Pain

Last updated on 5 January 2026 by Brisbane Livewell Clinic Editorial Team

Understanding the Causes of Knee Pain

Knee pain is a common issue that affects people of all ages. Whether it’s from an acute injury or a chronic condition, understanding the root causes is crucial for effective treatment and recovery.

What Causes Knee Pain?

Here are some of the main causes of knee pain: 

1. Injuries

Acute injuries like ligament tears (ACL, MCL), meniscus tears, and fractures can lead to immediate and severe knee pain, often requiring prompt attention.

2. Overuse Conditions

Conditions such as patellar tendinitis, IT band syndrome, and bursitis can develop from repetitive activities, causing pain and inflammation.

3. Arthritis

Forms of arthritis, including osteoarthritis, rheumatoid arthritis, and gout, can lead to knee pain, stiffness, and swelling, affecting adults of any age.

4. Mechanical Problems

Misalignment, dislocated kneecaps, or issues with your feet and hips can put extra stress on your knees, causing pain.

5. Degenerative Conditions

Age-related wear and tear can lead to conditions that cause knee pain and limit mobility.

6. Inflammation

Persistent inflammation can lead to ongoing pain, stiffness, and discomfort, affecting daily activities and overall well-being.

7. Fibromyalgia

Characterised by widespread musculoskeletal pain, fatigue, and tenderness in localised areas, fibromyalgia impacts both physical and mental health.

8. Ehlers-Danlos Syndrome (EDS)

This group of disorders affects connective tissues, leading to symptoms like overly flexible joints, stretchy skin, and fragile tissues, which can contribute to pain and potential injuries.

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Authors & Reviewers

Written by the Brisbane Livewell Clinic Editorial Team

Written by the Brisbane Livewell Clinic Editorial Team in accordance with our Editorial Policy and Content Standards.

Reviewed by Our Practitioners

Expert Review by our qualified Practitioners at Brisbane Livewell Clinic (Wavell Heights) and Brisbane Livewell Clinic (Cannon Hill). Our articles are reviewed for accuracy, AHPRA compliance (for Allied Health Services) and alignment with current evidence and best practice under our Editorial Policy and Content Standards.